GA 353 first came into existance in 1964 as a new route between Douglas and the Irwin County line, and was completely in Coffee County. For some reason, GA 353 came to a dead end at the Irwin County line. To compensate for that, GA 206 Spur was created as a stopgap measure between GA 353 and GA 206. That route ended up lasting for over 15 years, because the completion of a direct link between GA 353 and GA 206 was not completed until 1973. GA 206 Spur is today known as P. Griffin Road and part of Coffee C.R. 135, extending 1.0 miles. Oddly enough, GA 206 Spur remained on the state highway system until 1979.

GA 353 when it was first commissioned compared to GA 353 in its last years. Note the missing link in the first map and GA 206 Spur. The second map shows the extension of GA 353 to U.S. 221/441 (1964 GHD Map and 1986 GDOT Map).

In 1980, GA 353 was extended past its eastern terminus to directly connect to U.S. 221/441. This connection firmly established the highway as a major route. By the late 1980's, addictional by-passes were built around the city of Douglas, and suddenly the route was in a complex of other routes. By 1989, GA 206 was relocated along GA 353 with the former route of GA 206 turned back to local control, spelling the end of GA 353.